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Trinity Regional Health System (TRHS) is a three-campus health-care provider located on the western border of Illinois and the eastern border of Iowa. With a history dating back to the late 1800s, its campuses in Moline and Rock Island, Illinois, and Davenport, Iowa total 514-licensed beds and employ nearly 3,000 staff. Its parent corporation, Trinity Regional Health System, includes a network of services including three Trinity Women's Clinics, rural clinics and a PHO.

It includes Trinity Medical Center with its West Campus in Rock Island and 7th Street Campus in Moline, both in Illinois. Trinity is licensed for 344 beds on the West Campus and 20 post-surgical recovery care beds on the 7th Street Campus. Recently, Trinity added Trinity Medical Center North Campus in Davenport, Iowa (formerly Davenport Medical Center), a 150-bed acute care hospital. Other TRHS subsidiaries include the Robert Young Center for Community Mental Health, Trinity Health Enterprises, Inc., Trinity Visiting Nurse and Homemaker Association, Trinity Health Foundation, and Trinity Health Partners, a physician group. In Iowa Trinity also operates Women's Clinics in Bettendorf and Davenport, Trinity Home Care in Davenport, and is part owner of Work Fitness Center and Mississippi Medical Plaza. In addition, Trinity operates primary care clinics in Coal Valley, East Moline and Geneseo, Illinois. Trinity Regional Health System is a senior affiliate of the Iowa Health System based in Des Moines, Iowa.

Trinity's Cancer Center, the most experienced in the Quad-City area, is located on the 7th Street Campus in Moline. As one of only 52 community cancer centers in the nation distinguished by the National Cancer Institute (NCI) as a Community Clinical Oncology Program, Trinity's Cancer Center provides access in the Quad-Cities to 80 clinical trials. Trinity Cancer Center is affiliated with the Cedar Rapids Oncology Project, the North Central Cancer Treatment Group, and the Eastern Co-Operative Oncology Program. With these memberships Trinity has access to national clinical trials and major prevention studies from NCI-approved research groups.

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